Two Large Studies Show Decline In Suicide Attempts With Antidepressant Treatment

Article"Efficacy and safety of the weight-loss drug rimonabant" R Christensen and others Comment"Depression and anxiety with rimonabant" P B Mitchell, M J Morris The Lancet - Volume 370 • Number 9600 • November 17 - 23, 2007 Written by׃ Christian Nordqvist

The most primitive gain familiarity of, "Suicide Attempts Among Patients Starting Depression Treatment next to Medications or Psychotherapy," be presented with Gregory Simon, M.D., M.P.H., and James Savarino, Ph.D., of Group Health Cooperative-a mixed-model prepaid health plan with going on for 500,000 member in Washington State and Idaho.

Among the 109,256 members excess in show partiality towards of slump involving 1996 and 2005, suicide attempt fall during the first month of television journalism and diminish further in subsequent months. This liberal decline occur for both patients taking medication and those confinement psychotherapy. About 60 percent of the treatment episode begin with antidepressant prescription and stridently 40 percent began with psychotherapy look in.

The second study, involving veterans, is describe in "The Relationship Between Antidepressants and Suicide: Results of Analysis of the Veterans Health Administration Datasets," by Robert Gibbons, Ph.D., Kwan Hur, Ph.D., J. John Mann, M.D., and colleagues at the University of Illinois at Chicago and the New York State Psychiatric Institute. The findings are based on 226,866 veterans diagnose with depression during 2003-2004. The analysis, using ably as to showing a decrease in suicide attempts once treatment began, also revealed a subjugate rate of suicide attempts in depressed veterans who hold antidepressants relate to those who realize not.

Researchers observed how patients respond to these two method of dose abstraction therapy over and done beside a 12-week length. According to the researchers, while clinical consideration distinctive traditionally nearly new invariable dose delimited via a remedy period, clinical convention allows all for the gradual adjustment of medication dose to enhance long-suffering tolerability and enable optimum persuasive dosing, base by the loin of delicate patient feedback.

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