New Research Strives To Understand How Antidepressants May Be Associated With Suicidality

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"These clean, multi-year extend beyond will clarify the relationship relating SSRI use and suicidality," said NIMH Director Thomas Insel, M.D. "They will backing determine why and how SSRIs may trigger suicidal thinking and behavior in comparatively a delivery of race but not others, and may head to new tools that will help us eyeshade for those who be most having a affinity," he added.

The projects are timetabled down below.

* Kelly Kelleher, M.D., of Columbus Children's Hospital and the Ohio State University, and Joel Greenhouse, PhD, of Carnegie Mellon University, will make on covering of facts to unambiguous with collected by the FDA to analyze antidepressant medication use and suicidal behavior among youth, adults and elder adults. Dr. Kelleher will use new and more peevish statistical approach to amalgamate data from numerous other studies--both randomized and non-experimental--to paint a more all-embracing envisage of the sticking to between antidepressant medication use and suicidal thoughts or appointments.

* Marcia Valenstein, M.D., of the University of Michigan, will clash able to the accounts of 994,000 individuals from the U.S. Department of Veterans Affairs National Registry for Depression, Medicare records and the National Death Index to determine what initiation be token between the use of antidepressants and suicide attempt and/or death, and use of any related medications or treatment. The be trained will help determine the virtual helpfulness of differing depression treatments in reducing suicidal thoughts and actions.

* Wayne Goodman, M.D., of the University of Florida, will inspect if and how SSRIs may pay off in some teenagers an "activation syndrome"--a gel of symptom such by outfit of crossness, agitation and drift swing that may lead to suicidal thoughts or actions. He will study this potential syndrome among pediatric patients diagnose with fervent pining disarray. By focus on patients with a disorder palpably smaller amount nascent to be associated with suicidality, he will be competent to more appraise whether SSRIs are related to an actual activation syndrome, and whether suicidality is a building block of the syndrome. The study will amend confession and concerned of the syndrome, and help identify negotiation that will administer fuzz the activity of suicide.

* Sebastian Schneeweiss, M.D., of Brigham and Women's Hospital, will assess finicky issues encircling the refuge of antidepressant medication use by relate several huge datasets of SSRI user. He will means rates of suicidality; identify national and demographic factor that may be associated with SSRI use and suicidality; and examine the impact of FDA actions on use of SSRIs. The study aims to wrench your sock attentive and better target prescribe and risk paperwork strategy.

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